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Lovastatin

Lovastatin & ALA

Suppresses absorption of ALA. This medication is commonly used for High Cholesterol

Why Lovastatin affects ALA

Statins can lead to elevated liver enzymes, which may increase the risk of liver damage.  Studies suggest that liver injury can be associated with statins and potent antioxidants like alpha lipoic acid with its anti-inflammatory action is associated with improved liver circulation, hepatoprotective, and therapeutic in liver conditions and disease.

Clinical Evidence

Stanković MN, Mladenović D, Ninković M, Ethuričić I, Sobajić S, Jorgačević B, de Luka S, Vukicevic RJ, Radosavljević TS. The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine-choline deficient diet-induced NAFLD. J Med Food. 2014 Feb;17(2):254-61. De Denus S, Spinler SA, Miller K, et al. Statins and liver toxicity: a meta-analysis. Pharmacotherapy. 2004; 24(5):584-591. Alsheikh-Ali AA, Maddukuri PR, Han H, et al. Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer. Journal of the American College of Cardiology 2007;50:409-18. LaRosa JC, Grundy SM, Waters DD, et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. New England Journal of Medicine 2005;352:1425?]35. J Bustamante 1 , et al. . Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med. 1998 Apr;24(6):1023-39.

Recommended Replacement

Alpha Lipoic Acid100 mg

Other Nutrients Affected by Lovastatin

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