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Hydrochlorothiazide

Hydrochlorothiazide & Potassium

Depletes Potassium. This medication is commonly used for Hypertension

Why Hydrochlorothiazide affects Potassium

Thiazide diuretics can cause potassium to leave your cells. These medications work by making your kidneys flush out water and sodium, but unfortunately, potassium gets swept along too. This raises the risk of a moderate or severe potassium deficiency, called hypokalemia and potassium supplementation should be considered.

Clinical Evidence

Rodenburg EM, Visser LE, Hoorn EJ, Ruiter R, Lous JJ, Hofman A, Uitterlinden AG, Stricker BH. Thiazides and the risk of hypokalemia in the general population. J Hypertens. 2014 Oct;32(10):2092-7; discussion 2097. PMID: 25105457. Odvina CV, Mason RP, Pak CY. Prevention of thiazide-induced hypokalemia without magnesium depletion by potassium-magnesium-citrate. Am J Ther. 2006 Mar-Apr;13(2):101-8. . Low potassium levels from diuretics. January 23, 2017. Harvard Health Publishing.

Recommended Replacement

Potassium (as citrate and gluconate)99 mg

Related Health Impacts

  • Constipation & Rhythm Disturbances

    Low potassium slows smooth muscle activity in the gut, leading to constipation, and destabilizes cardiac repolarization, increasing risk of palpitations and dangerous arrhythmias in susceptible patients.

Supplement Recommendation

Potassium (as gluconate) by Pure Encapsulations200mg

Other Nutrients Affected by Hydrochlorothiazide

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