Hydrochlorothiazide

Hydrochlorothiazide is a medication primarily used to treat high blood pressure (hypertension) and edema (fluid retention) caused by various medical conditions such as heart failure, kidney disorders, or liver disease. It belongs to a class of drugs known as diuretics or "water pills," which help the body get rid of excess salt and water by increasing urine production. This helps lower blood pressure and decrease swelling in the body. Hydrochlorothiazide is often prescribed in combination with other blood pressure medications for better control of hypertension. It is usually taken by mouth in the form of a tablet.

Overview Why It Happens Clinical Evidence Replacement Other Nutrients

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Hydrochlorothiazide

Hydrochlorothiazide & Folic Acid

Depletes Folic Acid. This medication is commonly used for Hypertension

Why Hydrochlorothiazide affects Folic Acid

Studies indicate thiazide diuretics may act like folate antagonists, potentially leading to folate deficiency. Research suggests long-term use (over six months) can significantly decrease blood folate levels while increasing homocysteine, a potentially harmful amino acid linked to vascular disease. Folate supplementation should be considered while on thiazide diuretics.

Clinical Evidence

Maron BA, Loscalzo J. Homocysteine. Clin Lab Med. 2006 Sep;26(3):591-609, vi. doi: 10.1016/j.cll.2006.06.008. PMID: 16938586. Morrow LE, Grimsley EW. Long-term diuretic therapy in hypertensive patients: effects on serum homocysteine, vitamin B6, vitamin B12, and red blood cell folate concentrations. South Med J. 1999 Sep;92(9):866-70.

Recommended Replacement

Folate (.2mg as L-5-Methylfolate) — 0.34 DFE

Other Nutrients Affected by Hydrochlorothiazide

Potassium — Depletion
CoQ10 — Depletion
Zinc — Depletion
Magnesium — Depletion

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