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Hydrochlorothiazide

Hydrochlorothiazide & Magnesium

Depletes Magnesium. This medication is commonly used for Hypertension

Why Hydrochlorothiazide affects Magnesium

Taking thiazide diuretics long-term can increase magnesium loss. Monitoring magnesium levels and considering supplementation might be necessary when taking thiazide diuretics for an extended period of time.

Clinical Evidence

Cunha A.R., D’El-Rei J., Medeiros F., Umbelino B., Oigman W., Touyz R.M., Neves M.F. Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women. J. Hypertens. 2017;35:89–97. Martin B, Milligan K. Diuretic-associated hypomagnesiumia in the elderly. Arch Intern Med 1987;147:1768–71. Whang R, Whang DD, Ryan MP. Refractory potassium repletion. A consequence of magnesium deficiency. Arch Intern Med 1992;152:40-5.Gröber U., Schmidt J., Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015;7:8199–8226. doi: 10.3390/nu7095388

Recommended Replacement

Magnesium Citrate50 mg

Supplement Recommendation

Magnesium (as Magnesium Citrate) by Pure Encapsulations150 mg

Other Nutrients Affected by Hydrochlorothiazide

Next Steps
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