Low zinc disrupts keratinocyte proliferation, collagen synthesis and epithelial repair, resulting in delayed wound healing, dermatitis and poor tissue regeneration. This medication is commonly used for Stomach Acid.
Experimental and clinical studies demonstrate that zinc deficiency is associated with skin lesions, delayed wound closure and abnormal inflammatory responses, while zinc repletion can improve healing outcomes in selected populations.
Lin PH, Sermersheim M et al. Zinc in wound healing modulation. Nutrients. 2017;9(1):16.; News-Medical. The role of zinc in immune health and wound healing. 2024.; Lopez EA et al. Systematic review and meta-analysis of the effect of zinc on wound healing. Nutr Clin Pract. 2025;40(2):123-135.
Some side effects may be linked to nutrient depletion caused by this medication.
Long-term use of H2 blockers may increase your risk of zinc deficiency. These medications work by reducing stomach acid, which is crucial for absorbing zinc from food. Zinc is an essential mineral that supports a healthy immune system and wound healing. Deficiency can lead to various health problems. A study directly investigated the impact of cimetidine, a common H2 blocker, on zinc absorption. The research found that zinc absorption significantly decreased after cimetidine administration, highlighting the role of stomach acid in this process. Individuals who take H2 blockers for extended periods should consider supplementation with zinc to protect against a deficiency.
Research suggests that long-term use of H2 blockers and antacids might raise the risk of folic acid deficiency. These medications work by reducing stomach acid, which can also play a role in folic acid absorption. Folic acid is crucial for healthy cell growth and development, and a deficiency can lead to various health problems, especially during pregnancy. Some studies show a potential link between H2 blocker/antacid use and lower folic acid levels. Individuals who take H2 blockers or antacids for extended periods should consider supplementation with folic acid to protect against a deficiency.
Research suggests that long-term use of medications that reduce stomach acid, like H2 blockers and PPIs, may be linked to vitamin B12 deficiency. Stomach acid plays a role in releasing vitamin B12 from food, and reduced acid levels caused by these medications could hinder proper B12 absorption. Some studies find an increased risk of B12 deficiency, particularly in older adults or those using these medications for extended periods. Individuals taking H2 blockers or PPIs long-term should consider vitamin B12 supplementation.
Vitamin A plays a vital role in maintaining a healthy gut lining, which is crucial for overall stomach health. This is why some research has explored its potential use alongside other medications for treating ulcers. Research suggests vitamin A supplementation may be effective specifically for treating ulcers alongside H2 blockers.