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Ranitidine

Ranitidine & Zinc

Depletes Zinc. This medication is commonly used for Stomach Acid

Why Ranitidine affects Zinc

Long-term use of H2 blockers may increase your risk of zinc deficiency. These medications work by reducing stomach acid, which is crucial for absorbing zinc from food. Zinc is an essential mineral that supports a healthy immune system and wound healing. Deficiency can lead to various health problems. A study directly investigated the impact of cimetidine, a common H2 blocker, on zinc absorption. The research found that zinc absorption significantly decreased after cimetidine administration, highlighting the role of stomach acid in this process. Individuals who take H2 blockers for extended periods should consider supplementation with zinc to protect against a deficiency.

Clinical Evidence

Sturniolo GC, Montino MC, Rossetto L, Martin A, D'Inca R, D'Odorico A, Naccarato R. Inhibition of gastric acid secretion reduces zinc absorption in man. J Am Coll Nutr. 1991 Aug;10(4):372-5. Sa'adah MA, Al Salem M, Ali AS, Araj G, Zuriqat M. Cimetidine-associated optic neuropathy. Eur Neurol. 1999 Jul;42(1):23-6. Chao HC. Zinc Deficiency and Therapeutic Value of Zinc Supplementation in Pediatric Gastrointestinal Diseases. Nutrients. 2023 Sep 22;15(19):4093.

Recommended Replacement

Zinc Bisglycinate12.5 mg

Related Health Impacts

  • Weakened Immune Response

    Zinc depletion compromises innate and adaptive immune responses, leading to lymphopenia, reduced T-cell function and higher susceptibility to infections.

  • Slow Skin & Wound Healing

    Low zinc disrupts keratinocyte proliferation, collagen synthesis and epithelial repair, resulting in delayed wound healing, dermatitis and poor tissue regeneration.

Supplement Recommendation

Zinc Bisglycinate by Pure Encapsulations15 mg

Other Nutrients Affected by Ranitidine

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