Vitamin D plays a key role in muscle function, so deficiency can present with proximal muscle weakness, diffuse aches, and an increased risk of falls and difficulty rising from a chair or climbing stairs. Clinical reports describe patients with severe vitamin D deficiency and myopathy who regained normal muscle strength and mobility within about 4–6 weeks of treatment; in one series, four patients became fully mobile with normalized 25‑hydroxyvitamin D levels, and a fifth also became mobile even though parathyroid hormone levels, while lower, remained somewhat elevated. The practical takeaway is that, in people with otherwise unexplained muscle weakness, falls, and chronic musculoskeletal pain, checking and correcting vitamin D deficiency can lead to rapid, meaningful improvements in function and quality of life. This medication is commonly used for High Cholesterol.
Prabhala A, Garg R, Dandona P. Severe myopathy associated with vitamin D deficiency in western New York. Arch Intern Med. 2000 Apr 24;160(8):1199-203. Appel LJ, Michos ED, Mitchell CM, Blackford AL, Sternberg AL, Miller ER 3rd, Juraschek SP, Schrack JA, Szanton SL, Charleston J, Minotti M, Baksh SN, Christenson RH, Coresh J, Drye LT, Guralnik JM, Kalyani RR, Plante TB, Shade DM, Roth DL, Tonascia J; STURDY Collaborative Research Group. The Effects of Four Doses of Vitamin D Supplements on Falls in Older Adults : A Response-Adaptive, Randomized Clinical Trial. Ann Intern Med. 2021 Feb;174(2):145-156. Borim FSA, Alexandre TDS, Neri AL, Máximo RO, Silva MF, de Oliveira C. Combined Effect of Dynapenia (Muscle Weakness) and Low Vitamin D Status on Incident Disability. J Am Med Dir Assoc. 2019 Jan;20(1):47-52. Lois Baker. UB Endocrinologist Reports First U.S. Cases Of Severe Muscle Weakness Due To Vitamin D Deficiency. University of Buffalo. April 2000.
Some side effects may be linked to nutrient depletion caused by this medication.
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to folic acid, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with folic acid may be advisable to prevent or address potential deficiencies.
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin A, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin A may be advisable to prevent or address potential deficiencies.
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin D3, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin D3 may be advisable to prevent or address potential deficiencies.
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin E, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin E may be advisable to prevent or address potential deficiencies.