Questran

Questran is a brand name for the drug cholestyramine, which is used to lower cholesterol levels in the blood. It works by binding to bile acids in the intestine, preventing them from being reabsorbed into the bloodstream, which helps lower cholesterol levels. Questran is typically prescribed to people with high cholesterol or certain types of diarrhea.

Overview Why It Happens Clinical Evidence Replacement Supplement Other Nutrients

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Questran

Questran & Vitamin E

Depletes Vitamin E. This medication is commonly used for High Cholesterol

Why Questran affects Vitamin E

Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin E, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin E may be advisable to prevent or address potential deficiencies.

Clinical Evidence

Threlkeld DS, ed. Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.M S Matsui et al. Drug-nutrient interaction. Clin Ther. 1982;4(6):423-40.Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 224.

Recommended Replacement

Vitamin E (d-alpha tocopherol with mixed tocopherols) — 30 IU

Supplement Recommendation

Vitamin E (d-alpha tocopherol) 33 mg; mixed tocopherols 6.6mg (providing d-gamma, d-delta and d-beta tocopherols) by Life Extension — 50 IU

Other Nutrients Affected by Questran

Folic Acid — Depletion
Vitamin A — Depletion
Vitamin D3 — Depletion

Next Steps

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