Suppresses absorption of NAC. This medication is commonly used for Pain Management
Studies suggest that acetaminophen may cause liver damage in high doses or with certain risk factors. N-acetylcysteine (NAC) has been shown to offer protective benefits for the liver against the potential toxic effects of acetaminophen.
Hendrickson RG. What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose? Clin Toxicol (Phila). 2019 Aug;57(8):686-691. Buckley N, Eddleston M. Paracetamol (acetaminophen) poisoning. BMJ Clin Evid. 2007 Dec 4;2007:2101. Perry HE, Shannon MW. J Pediatr 1998;132:149-52. Vale JA, Proudfoot AT. Paracetamol (acetaminophen) poisoning. Lancet 1995;346:547-52. Martin J. Smilkstein, M.D., Gary L. Knapp, et al. Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose. N Engl J Med 1988; 319:1557-1562
N-Acetylcysteine — 200 mg
N-acetylcysteine is a precursor of cysteine for glutathione synthesis; inadequate NAC availability in high-toxin states can limit hepatic glutathione, increasing vulnerability to oxidative and drug-induced liver injury.