Suppresses absorption of Milk Thistle. This medication is commonly used for Pain Management
Milk thistle (Silybum marianum) contains a group of complex flavonoids called silymarin. This natural compound has been shown to increase glutathione levels in the liver. Acetaminophen, a widely used pain reliever and fever reducer, can be harmful to the liver in high doses or for people with certain risk factors. Research suggests that silymarin may help elevate glutathione levels within the liver. Glutathione is an important antioxidant that the body uses to combat damage, and its depletion is believed to play a role in how acetaminophen harms the liver.
Abdilkerim Oyman, et al. Protective Effects of Silymarin on Acetaminophen-Induced Toxic Hepatitis. EJMA 2022;2(1):1–6. Noor Ahmed Abed, et al. The Protective Effect of Milk Thistle Against Drug-Induced Renal Illnesses: A Review. Researchgate Dec 2022. Campos R, Garrido A, Guerra R, Valenzuela A. Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Med 1989;55:417-9.
Milk Thistle (Silybum marianum) (seed) Standardized 80% Silymarin Flavonoids) — 200 mg
Silymarin from milk thistle has antioxidant and antifibrotic properties in hepatocytes; lack of this protective input in high-stress liver states may permit more oxidative and inflammatory damage, although a formal deficiency state is not defined.
Because well-controlled trials have not demonstrated large improvements in fibrosis or mortality with silymarin, absence of milk thistle is unlikely to cause a distinct clinical syndrome, though it may remove a small protective effect in chronic liver disease.
Milk Thistle (Silybum marianum) (seed) Standardized 80% Silymarin Flavonoids) by Pure Encapsulations — 250 mg