Zinc deficiency often first shows up on the skin, with acrodermatitis‑like eruptions around the mouth, perineum, and distal extremities, accompanied by alopecia and sometimes nail changes. Characteristic lesions can be erythematous, scaly, or pustular, and both congenital and acquired zinc deficiency states have been reported to improve dramatically within days to weeks of adequate zinc repletion. Clinically, zinc is also crucial for normal collagen synthesis and immune function in the skin, so deficiency is linked to delayed wound healing and weaker scars, whereas restoring zinc status can enhance re‑epithelialization and reduce wound complications. This medication is commonly used for Hypertension.
Kelly S, Stelzer JW, Esplin N, Farooq A, Karasik O. Acquired Acrodermatitis Enteropathica: A Case Study. Cureus. 2017 Sep 8;9(9):e1667. Alwadany MM, Al Wadani AF, Almarri FH, Alyami HS, Al-Subaie MA. Acrodermatitis Enteropathica: A Rare Case With Lifelong Implications. Cureus. 2023 Apr 18;15(4):e37783. Al-Khafaji Z, Brito S, Bin BH. Zinc and Zinc Transporters in Dermatology. Int J Mol Sci. 2022 Dec 18;23(24):16165. Ogawa Y, Kinoshita M, Shimada S, Kawamura T. Zinc and Skin Disorders. Nutrients. 2018 Feb 11;10(2):199.
Some side effects may be linked to nutrient depletion caused by this medication.
This drug is a comprehensive combination of a calcium channel blocker and angiotensin receptor blocker. Calcium channel blockers (CCBs), particularly nifedipine, can cause gum tissue overgrowth (gingival hyperplasia) in both men and women. Studies suggest a dose-dependent link with CCBs potentially doubling the risk. Studies also confirm a link between CCB use (like amlodipine and nifedipine) and gingival hyperplasia, even beyond factors like poor hygiene. Research suggests impaired folate uptake in gum tissue might be another key contributor. Supplementation with folate to help protect against CCB-induced hyperplasia may be beneficial.
This drug is a comprehensive combination of a calcium channel blocker and angiotensin receptor blocker. Studies have shown that treatment with medications like Angiotensin Receptor Blockers (ARBs) can lead to zincuria, which is increased urinary excretion of zinc. This increased excretion may potentially lead to zinc deficiency in some individuals and therefore supplementation should be considered.