Depletes Zinc. This medication is commonly used for Hypertension
This drug is a comprehensive combination of a calcium channel blocker and angiotensin receptor blocker. Studies have shown that treatment with medications like Angiotensin Receptor Blockers (ARBs) can lead to zincuria, which is increased urinary excretion of zinc. This increased excretion may potentially lead to zinc deficiency in some individuals and therefore supplementation should be considered.
Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract. 2013 Aug;67(8):717-25. Maya Koren-Michowitz, Victor Dishy, Ronit Zaidenstein, Orit Yona, Sylvia Berman, Joshua Weissgarten, Ahuva Golik, The effect of losartan and losartan/hydrochlorothiazide fixed-combination on magnesium, zinc, and nitric oxide metabolism in hypertensive patients: A prospective open-label study, American Journal of Hypertension, Volume 18, Issue 3, March 2005, Pages 358–363. Cohen, N., Golik, A. Zinc balance and medications commonly used in the management of heart failure. Heart Fail Rev 11, 19–24 (2006).
Zinc (as zinc bisglycinate and (TRAACS™) — 12.5 mg
Low zinc status has been linked to a higher risk and faster progression of age-related macular degeneration (AMD), in part because zinc is concentrated in the retina and supports antioxidant defenses there. In the landmark AREDS trial, a supplement formula containing zinc (80 mg as zinc oxide), along with antioxidants, reduced the risk of progression to advanced AMD by about 25% in people with intermediate disease or advanced disease in one eye over roughly 5 years. Other research has shown that inadequate zinc intake is more common in older adults with AMD, reinforcing the idea that maintaining healthy zinc levels may be an important, and often overlooked, strategy for preserving macular health with age.
Closely linked to reproductive and hormonal problems in both men and women, zinc deficiency can contribute to hypogonadism, low testosterone, reduced sperm count, and menstrual irregularities. In men, low zinc status has been associated with decreased serum testosterone, reduced sperm density and motility, and poorer overall semen quality, while zinc repletion in deficient individuals has been shown to improve some of these parameters. In women, inadequate zinc intake is tied to more frequent cycle disturbances, dysmenorrhea, and potential impacts on ovulation and fertility, underscoring zinc’s important role in healthy hormonal balance and reproductive function.
Zinc Bisglycinate by Pure Encapsulations — 15 mg