Vitamin C deficiency weakens collagen in capillary and vascular walls, so severe scurvy can present with ocular hemorrhages in the conjunctiva and retina that threaten vision if not treated. Case reports and small series describe retinal hemorrhages, flame‑shaped hemorrhages, and even retrobulbar bleeding compressing the optic nerve, which can lead to optic neuropathy and visual loss in advanced cases. The encouraging point is that, when vitamin C deficiency is recognized early and promptly repleted, many ocular hemorrhages and visual symptoms can partially or fully resolve, making it critical to consider vitamin C status in patients with otherwise unexplained ocular bleeding and visual complaints. This medication is commonly used for Pain Management.
Errera MH, Dupas B, Man H, Gualino V, Gaudric A, Massin P. Une cause inhabituelle d'anomalies rétiniennes, hémorragies rétiniennes révélatrices de scorbut [Unusual retinal abnormality: retinal hemorrhages related to scurvy]. J Fr Ophtalmol. 2011 Mar;34(3):186.e1-3. Masuda Y, Saigusa K, Norisue Y. A Case of Scurvy Associated With Intracerebral Hemorrhage in a Patient With Alcohol Use Disorder. Cureus. 2024 Feb 23;16(2):e54777. Andrew Go Lee, et al. Ocular Manifestations of Vitamin C Deficiency. American Academy of Opthamology. November 2025. A. Martel, et al. Spontaneous eyelid and subconjunctival socket bleeding related to vitamin C deficiency: First case reportHémorragie palpébrale et sous conjonctivale spontanée sur cavité anophtalme secondaire à un déficit en vitamine C : premier cas rapporté. Journal Français d'Ophtalmologie. Volume 43, Issue 9, November 2020.
Some side effects may be linked to nutrient depletion caused by this medication.
Research suggests that taking Vitamin C alongside Acetaminophen might prolong the medication's presence in the bloodstream. This could potentially allow for lower Acetaminophen doses, thereby reducing the risk of side effects.