Depletes Vitamin A. This medication is commonly used for High Cholesterol
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin A, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin A may be advisable to prevent or address potential deficiencies.
Probstfield JL, Lin TL, Peters J, Hunninghake DB. Carotenoids and vitamin A: the effect of hypocholesterolemic agents on serum levels. Metabolism. 1985 Jan;34(1):88-91. doi: 10.1016/0026-0495(85)90066-6. PMID: 3965864.Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 224 [review]. Threlkeld DS, ed. Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.
67% Retinol;33% Beta carotene — 1,500 IU
Vitamin A deficiency can damage the surface of the eye in both children and adults, progressing from dry, uncomfortable eyes and night‑vision problems to xerophthalmia and, in severe cases, permanent blindness if it is missed. Regular vitamin A from food and, when appropriate, thoughtfully used supplements can meaningfully reduce this risk; in one large analysis, children in the highest overall intake group had about a 62 percent lower risk of xerophthalmia than those in the lowest group (multivariate relative risk 0.38, 95 percent confidence interval 0.19–0.74). Vitamin A deficiency and xerophthalmia have been documented not just in low‑resource settings but also in at‑risk children and adults in developed countries, so anyone with unexplained dry eyes, night‑vision changes, or corneal findings should have vitamin A status considered and be referred promptly for ophthalmology review to help protect their sight.
Low vitamin A status can quietly undermine reproductive health, because vitamin A is deeply involved in egg and sperm development, maintenance of reproductive tissues, and the signaling events that trigger meiosis in both the female and male gonad. Studies in pregnant women in rural South Asia show that bringing vitamin A intake closer to recommended levels markedly reduced, but did not fully eliminate, night blindness during pregnancy and postpartum, suggesting that vitamin A supplementation, alongside other key nutrients, may be required to fully protect maternal vision and status. For individuals with fertility challenges or for pregnant women reporting new night‑vision problems, proactively assessing vitamin A status and considering targeted, evidence‑based supplementation protocols can be an important strategy to improve reproductive outcomes and reduce adverse pregnancy risks
Vitamin A and beta carotene are essential for maintaining the integrity of the cornea and the light-sensing pigments in the retina, so deficiency greatly increases the risk of night blindness and other ocular pathologies. In vitamin A deficient regions, hundreds of thousands of children each year develop xerophthalmia, ranging from conjunctival and corneal dryness to corneal ulceration and keratomalacia, which can progress to irreversible blindness if not corrected. Even subclinical deficiency can impair dark adaptation and increase susceptibility to eye infections, making adequate vitamin A and carotenoid intake a critical foundation for long-term visual health.
Vitamin A (Beta Carotene -25% ; Retinyl Palmitate-75%) by Solaray — 7500 mcg