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Prednisone

Prednisone & Magnesium

Depletes Magnesium. This medication is commonly used for Inflammation

Why Prednisone affects Magnesium

Corticosteroids can increase the body's excretion of magnesium, potentially leading to a deficiency. This is concerning because magnesium plays a vital role in many bodily functions, including muscle and nerve function. Research suggests that magnesium supplementation alleviated corticosteroid therapy associated muscle atrophy. Supplementation with magnesium should be considered during long term corticosteroid therapy.

Clinical Evidence

Schutten JC, Joris PJ, Minović I, Post A, van Beek AP, de Borst MH, Mensink RP, Bakker SJL. Long-term magnesium supplementation improves glucocorticoid metabolism: A post-hoc analysis of an intervention trial. Clin Endocrinol (Oxf). 2021 Feb;94(2):150-157.Zheng L, Huang L, Chen Z, Cui C, Zhang R, Qin L. Magnesium supplementation alleviates corticosteroid-associated muscle atrophy in rats. Eur J Nutr. 2021 Dec;60(8):4379-4392. McKay LI, Cidlowski JA. Physiologic and Pharmacologic Effects of Corticosteroids. In: Kufe DW, Pollock RE, Weichselbaum RR, et al., editors. Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; 2003.

Recommended Replacement

Magnesium Citrate75 mg

Supplement Recommendation

Magnesium (as Magnesium Citrate) by Pure Encapsulations150 mg

Other Nutrients Affected by Prednisone

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