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Omeprazole

Omeprazole & Magnesium

Depletes Magnesium. This medication is commonly used for Stomach Acid

Why Omeprazole affects Magnesium

Studies find that proton pump inhibitors (PPIs) may increase your risk of magnesium deficiency. A large study involving over 100,000 participants found a significant association between PPI use and lower magnesium levels (hypomagnesemia). PPIs work by reducing stomach acid production, which can also play a role in magnesium absorption. Individuals taking PPIs, particularly long-term use, should consider magnesium supplementation to help protect against deficiency.

Clinical Evidence

Cheungpasitporn W, Thongprayoon C, Kittanamongkolchai W, Srivali N, Edmonds PJ, Ungprasert P, O'Corragain OA, Korpaisarn S, Erickson SB. Proton pump inhibitors linked to hypomagnesemia: a systematic review and meta-analysis of observational studies. Ren Fail. 2015 Aug;37(7):1237-41. William JH, Danziger J. Proton-pump inhibitor-induced hypomagnesemia: Current research and proposed mechanisms. World J Nephrol. 2016 Mar 6;5(2):152-7. Heidelbaugh JJ. Proton pump inhibitors and risk of vitamin and mineral deficiency: evidence and clinical implications. Ther Adv Drug Saf. 2013 Jun;4(3):125-33. Srinutta, Thawin MDa; Chewcharat, Api MDa; Takkavatakarn, Kullaya MDa; Praditpornsilpa, Kearkiat MDa; Eiam-Ong, Somchai MDa; Jaber, Bertrand L. MD, MSb,c; Susantitaphong, Paweena MD, PhDa,d,∗. Proton pump inhibitors and hypomagnesemia: A meta-analysis of observational studies. Medicine 98(44):p e17788, November 2019.

Recommended Replacement

Magnesium Citrate75 mg

Related Health Impacts

Supplement Recommendation

Magnesium (as Magnesium Citrate) by Pure Encapsulations150 mg

Other Nutrients Affected by Omeprazole

Next Steps
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