Zinc depletion compromises innate and adaptive immune responses, leading to lymphopenia, reduced T-cell function and higher susceptibility to infections. This medication is commonly used for Hypertension.
Classic dermatology and immunology literature shows that zinc deficiency causes lymphopenia and reduced immune capacity; more recent work links marginal deficiency to impaired inflammatory and anti-microbial responses.
Fraker PJ et al. The dynamic link between the integrity of the immune system and zinc status. JAMA Dermatol. 1987;123(2):169-174.; Lopez EA et al. Systematic review and meta-analysis of the effect of zinc on wound healing. Nutr Clin Pract. 2025;40(2):123-135.
Some side effects may be linked to nutrient depletion caused by this medication.
Studies have shown that treatment with medications like Angiotensin Receptor Blockers (ARBs) can lead to zincuria, which is increased urinary excretion of zinc. This increased excretion may potentially lead to zinc deficiency in some individuals and therefore supplementation should be considered.