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Losartan

Losartan & Zinc

Depletes Zinc. This medication is commonly used for Hypertension

Why Losartan affects Zinc

Studies have shown that treatment with medications like Angiotensin Receptor Blockers (ARBs) can lead to zincuria, which is increased urinary excretion of zinc. This increased excretion may potentially lead to zinc deficiency in some individuals and therefore supplementation should be considered.

Clinical Evidence

Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract. 2013 Aug;67(8):717-25. Maya Koren-Michowitz, Victor Dishy, Ronit Zaidenstein, Orit Yona, Sylvia Berman, Joshua Weissgarten, Ahuva Golik, The effect of losartan and losartan/hydrochlorothiazide fixed-combination on magnesium, zinc, and nitric oxide metabolism in hypertensive patients: A prospective open-label study, American Journal of Hypertension, Volume 18, Issue 3, March 2005, Pages 358–363. Cohen, N., Golik, A. Zinc balance and medications commonly used in the management of heart failure. Heart Fail Rev 11, 19–24 (2006).

Recommended Replacement

Zinc (as zinc bisglycinate and (TRAACS™)12.5 mg

Related Health Impacts

  • Weakened Immune Response

    Zinc depletion compromises innate and adaptive immune responses, leading to lymphopenia, reduced T-cell function and higher susceptibility to infections.

  • Slow Skin & Wound Healing

    Low zinc disrupts keratinocyte proliferation, collagen synthesis and epithelial repair, resulting in delayed wound healing, dermatitis and poor tissue regeneration.

Supplement Recommendation

Zinc Bisglycinate by Pure Encapsulations15 mg

Next Steps
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