Zinc depletion compromises innate and adaptive immune responses, leading to lymphopenia, reduced T-cell function and higher susceptibility to infections. This medication is commonly used for Hypertension.
Classic dermatology and immunology literature shows that zinc deficiency causes lymphopenia and reduced immune capacity; more recent work links marginal deficiency to impaired inflammatory and anti-microbial responses.
Fraker PJ et al. The dynamic link between the integrity of the immune system and zinc status. JAMA Dermatol. 1987;123(2):169-174.; Lopez EA et al. Systematic review and meta-analysis of the effect of zinc on wound healing. Nutr Clin Pract. 2025;40(2):123-135.
Some side effects may be linked to nutrient depletion caused by this medication.
Research suggests a link between ACE inhibitor use and insufficient zinc levels. Studies have found that patients taking ACE inhibitors exhibit higher levels of zinc in their urine and lower levels in their blood serum. This indicates that the medication may increase zinc excretion from the body, potentially leading to a deficiency. Individuals taking ACE inhibitors should be aware of this potential risk and consider zinc supplementation.