Low zinc disrupts keratinocyte proliferation, collagen synthesis and epithelial repair, resulting in delayed wound healing, dermatitis and poor tissue regeneration. This medication is commonly used for Hypertension.
Experimental and clinical studies demonstrate that zinc deficiency is associated with skin lesions, delayed wound closure and abnormal inflammatory responses, while zinc repletion can improve healing outcomes in selected populations.
Lin PH, Sermersheim M et al. Zinc in wound healing modulation. Nutrients. 2017;9(1):16.; News-Medical. The role of zinc in immune health and wound healing. 2024.; Lopez EA et al. Systematic review and meta-analysis of the effect of zinc on wound healing. Nutr Clin Pract. 2025;40(2):123-135.
Some side effects may be linked to nutrient depletion caused by this medication.
Research suggests a link between ACE inhibitor use and insufficient zinc levels. Studies have found that patients taking ACE inhibitors exhibit higher levels of zinc in their urine and lower levels in their blood serum. This indicates that the medication may increase zinc excretion from the body, potentially leading to a deficiency. Individuals taking ACE inhibitors should be aware of this potential risk and consider zinc supplementation.