Vitamin C shortfalls can matter more than people realize because they can quietly undermine iron status and contribute to microcytic, iron‑deficiency–type anemia. Vitamin C is one of the few nutrients that significantly boosts non‑heme iron absorption, helping convert dietary iron into a form the gut can take up more easily and counteracting common inhibitors found in grains, legumes, tea, and coffee. In people whose diets are low in both iron and vitamin C, this combination can show up as persistent fatigue, pallor, and microcytic red blood cells on lab work, with studies in iron‑depleted women showing that added ascorbic acid improved iron absorption and anemia markers over just a few weeks. This medication is commonly used for Pain Management.
Alhatem A, Cai D. Behind the Skin: A Rare Case of Scurvy-Associated Megaloblastic Anemia. Clin Med Insights Case Rep. 2019 May 10;12:1179547619849036. Ricaurte FR, Kewan T, Daw H. Scurvy: A Rare Cause of Anemia. Cureus. 2019 Sep 18;11(9):e5694.Golding PH. Experimental folate deficiency in human subjects: what is the influence of vitamin C status on time taken to develop megaloblastic anaemia? BMC Hematol. 2018 Jun 19;18:13. Kim YL. Vitamin C and functional iron deficiency anemia in hemodialysis. Kidney Res Clin Pract. 2012 Mar;31(1):1-3.
Some side effects may be linked to nutrient depletion caused by this medication.
Studies suggest that indomethacin, a type of nonsteroidal anti-inflammatory drug (NSAID), might decrease calcium levels in the body. To prevent potential calcium deficiency, supplementation should be considered for individuals taking indomethacin on a long-term basis.
Indomethacin, a medication commonly used to treat inflammation and pain, can decrease the absorption of vitamin C. Vitamin C plays a vital role in immune function and the body's antioxidant defenses. To counteract this effect and maintain a healthy immune system and antioxidant capacity, vitamin C supplementation is recommended for individuals taking Indomethacin.