Low calcium levels overstimulate nerves and muscles, leading to muscle cramps, spasms, and twitching. More significant deficiency can cause tetany, a state of sustained, painful muscle contractions often with carpopedal spasms and tingling around the mouth, hands, and feet. In severe cases, untreated hypocalcemia may progress to breathing difficulties from laryngospasm, seizures, abnormal heart rhythms, and other potentially life‑threatening complications. This medication is commonly used for Pain Management.
Agrawal A, Suryakumar G, Rathor R. Role of defective Ca2+ signaling in skeletal muscle weakness: Pharmacological implications. J Cell Commun Signal. 2018 Dec;12(4):645-659. Uday S, Högler W. Nutritional Rickets and Osteomalacia in the Twenty-first Century: Revised Concepts, Public Health, and Prevention Strategies. Curr Osteoporos Rep. 2017 Aug;15(4):293-302. Basma A. Dahash, et al. Rickets. StatPearls August 7, 2023. Seema M. Policepatil, et al. Hypocalcemic Myopathy Secondary to Hypoparathyroidism.Aloke A, Singh K. An Unusual Presentation of Multifactorial Hypocalcemia as Myopathy: A Case Report. Cureus. 2025 Jul 7;17(7):e87434.
Some side effects may be linked to nutrient depletion caused by this medication.
Studies suggest that indomethacin, a type of nonsteroidal anti-inflammatory drug (NSAID), might decrease calcium levels in the body. To prevent potential calcium deficiency, supplementation should be considered for individuals taking indomethacin on a long-term basis.
Indomethacin, a medication commonly used to treat inflammation and pain, can decrease the absorption of vitamin C. Vitamin C plays a vital role in immune function and the body's antioxidant defenses. To counteract this effect and maintain a healthy immune system and antioxidant capacity, vitamin C supplementation is recommended for individuals taking Indomethacin.