Across the lifespan, chronically low calcium intake has been linked to higher blood pressure, in part because calcium plays a key role in vascular smooth‑muscle contraction, sodium handling, and endothelial function. Large epidemiologic studies and randomized trials suggest that individuals with higher dietary calcium intake tend to have modestly lower systolic and diastolic blood pressures and may experience a small but meaningful reduction in risk of stroke and other cardiovascular events. The practical takeaway is that maintaining adequate daily calcium, alongside blood pressure control, exercise, and a heart‑healthy diet, may be an underutilized strategy to support vascular health and reduce long‑term cardiovascular risk. This medication is commonly used for Pain Management.
Kim MH, Bu SY, Choi MK. Daily calcium intake and its relation to blood pressure, blood lipids, and oxidative stress biomarkers in hypertensive and normotensive subjects. Nutr Res Pract. 2012 Oct;6(5):421-8. Hamer O, Mohamed A, Ali-Heybe Z, Schnieder E, Hill JE. Calcium supplementation for the prevention of hypertension: a synthesis of existing evidence and implications for practise. Br J Card Nurs. 2024 Feb 24;19(2):0010. Cheng, L., Lian, J., Ding, Y., Wang, X., Munir, M. A. M., Ullah, S., Wang, E., He, Z., & Yang, X. (2024). Calcium deficiency and its implications for cardiovascular disease and cancer: Strategies for resolution via agronomic fortification. Food Science & Nutrition, 12, 8594–8607.
Some side effects may be linked to nutrient depletion caused by this medication.
Indomethacin, a medication commonly used to treat inflammation and pain, can decrease the absorption of vitamin C. Vitamin C plays a vital role in immune function and the body's antioxidant defenses. To counteract this effect and maintain a healthy immune system and antioxidant capacity, vitamin C supplementation is recommended for individuals taking Indomethacin.
Studies suggest that indomethacin, a type of nonsteroidal anti-inflammatory drug (NSAID), might decrease calcium levels in the body. To prevent potential calcium deficiency, supplementation should be considered for individuals taking indomethacin on a long-term basis.