Depletes Folic Acid. This medication is commonly used for Pain Management
Regular use of non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen may decrease your folic acid (folate) levels. This is because NSAIDs can interfere with how your body processes folate. If you take OTC pain relievers regularly, consider folate supplementation to avoid potential deficiencies.
Baggott JE, Morgan SL, Taisun HA, Vaughn WH, Hine RJ. Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs. Biochem J. 1992;282:197-202. Boullata, Joseph and Vincent Armenti. Handbook of Drug-Nutrient Interactions. Totowa, New Jersey: Humana Press, 2004.
Folate (.2mg as L-5-Methylfolate) — 0.34 DFE