Felodipine & Magnesium
Depletes Magnesium. This medication is commonly used for Hypertension
Why Felodipine affects Magnesium
Research suggests that Felodipine, a type of calcium channel blocker (CCB), may increase the excretion of magnesium in the urine. This can potentially lead to magnesium deficiency. Studies have shown an increase in fractional excretion of magnesium following felodipine treatment, and the drug may also alter how magnesium moves across red blood cell membranes. Therefore supplementation with magnesium should be considered when on this therapy.
Clinical Evidence
Hulthén UL, Katzman PL. Renal effects of acute and long-term treatment with felodipine in essential hypertension. J Hypertens. 1988 Mar;6(3):231-7. doi: 10.1097/00004872-198803000-00008. PMID: 3361121. Hespel P, Lijnen P, Fiocchi R, Lissens W, Amery A. Effect of calcium antagonism on intracellular concentrations and transmembrane fluxes of cations in erythrocytes of men at rest and during exercise. J Hypertens. 1986 Dec;4(6):767-72.
Recommended Replacement
Magnesium Citrate — 50 mg
Related Health Impacts
- Irregular Heartbeat & Heart Risks
Low or depleted magnesium levels are associated with a higher likelihood of several cardiovascular problems, including arrhythmias, where people with low magnesium have been shown to have 2–4 times higher odds of these rhythm disturbances compared with those with normal levels. Low magnesium is also linked to worsening coronary artery disease, progression of heart failure, and development or aggravation of hypertension, driven by disrupted cardiac electrical stability, vascular function, and electrolyte balance. Even mild magnesium depletion may contribute to higher blood pressure over time, adding to the overall cardiovascular burden, especially in individuals with existing heart disease or multiple risk factors.
- Type 2 Diabetes & Metabolic Syndrome
Low or depleted magnesium levels place people with diabetes and metabolic syndrome (MetSyn) at higher risk of worsening glycemic control and insulin resistance because magnesium is essential for normal glucose metabolism and beta-cell function. When magnesium is low, these metabolic pathways become less efficient, amplifying blood sugar instability, lipid abnormalities, and other MetSyn features. Even moderate depletion can accelerate type 2 diabetes and MetSyn-related complications, underscoring the need for monitoring magnesium status in these vulnerable groups.
- Weak Bones & Fractures
Low or depleted magnesium levels are associated with a higher risk of osteoporosis and fractures, with studies linking magnesium deficiency to a 25–35% increased risk of hip, wrist, and spine fractures in some populations. Magnesium deficiency impairs bone mineralization and vitamin D activation, compounding skeletal weakness by disrupting osteoblast function and calcium balance. This is particularly concerning for older adults or those with additional risk factors, where monitoring magnesium status and considering supplementation may help mitigate bone loss.
Supplement Recommendation
Magnesium (as Magnesium Citrate) by Pure Encapsulations — 150 mg
Other Nutrients Affected by Felodipine
Get Support
Prolonged use of Felodipine can leave gaps in your nutrition. A targeted supplement can help restore balance while you continue treatment.
Amlodipine Support™
A bespoke formula designed to replenish the nutrients depleted by Felodipine.
Once Daily Capsule · Rx Not Required
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