Depletes Vitamin E. This medication is commonly used for High Cholesterol
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin E, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin E may be advisable to prevent or address potential deficiencies.
Threlkeld DS, ed. Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.M S Matsui et al. Drug-nutrient interaction. Clin Ther. 1982;4(6):423-40.Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 224.
Vitamin E (d-alpha tocopherol with mixed tocopherols) — 30 IU
In both children and adults, vitamin E deficiency can contribute to retinopathy and visual impairment because α‑tocopherol serves as a key fat‑soluble antioxidant that protects photoreceptor cells and retinal membranes from cumulative oxidative damage. Clinical reports describe patients with prolonged low vitamin E status developing pigmentary retinopathy, reduced visual acuity, and abnormal electroretinograms, sometimes alongside peripheral neuropathy, which can improve partially when deficiency is identified and corrected. These neurosensory changes appear more frequently in settings of fat malabsorption or genetic disorders affecting vitamin E transport, highlighting the importance of monitoring vitamin E status in at‑risk groups with otherwise unexplained visual decline.
Vitamin E (d-alpha tocopherol) 33 mg; mixed tocopherols 6.6mg (providing d-gamma, d-delta and d-beta tocopherols) by Life Extension — 50 IU