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Colesevelam

More Severe Infections

Vitamin A deficiency does not just affect vision; it also weakens the body’s front‑line defenses against infection, so common illnesses can become more severe, harder to recover from, and, in some cases, life‑threatening. In resource‑poor settings where diets are marginal and repeated gut infections are common, low vitamin A stores and ongoing inflammation often travel together, and infections like measles can drive serum vitamin A down by more than 30 percent at the very moment the immune system needs it most. For a child or adult facing frequent or unusually severe infections, especially in the context of poor diet or chronic gastrointestinal problems, it can be eye‑opening to realize that a hidden vitamin A gap may be quietly amplifying the risk of complications and mortality in otherwise “routine” illnesses. This medication is commonly used for High Cholesterol.

Sources

Coutsoudis A, Broughton M, Coovadia HM. Vitamin A supplementation reduces measles morbidity in young African children: a randomized, placebo-controlled, double-blind trial. Am J Clin Nutr. 1991 Nov;54(5):890-5. Imdad A, Mayo-Wilson E, Haykal MR, Regan A, Sidhu J, Smith A, Bhutta ZA. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database Syst Rev. 2022 Mar 16;3(3):CD008524. Christopher Hodge; Christopher Taylor. Vitamin A Deficiency. StatPearls. January 2, 2023. Vitamin A supplementation in northern Ghana: effects on clinic attendances, hospital admissions, and child mortality. Ghana VAST Study Team. Lancet. 1993 Jul 3;342(8862):7-12. Erratum in: Lancet 1993 Jul 24;342(8865):250. PMID: 8100345.

Nutrients Depleted by Colesevelam

Some side effects may be linked to nutrient depletion caused by this medication.

  • Folic AcidDepletion

    Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to folic acid, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with folic acid may be advisable to prevent or address potential deficiencies.

  • Vitamin D3Depletion

    Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin D3, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin D3 may be advisable to prevent or address potential deficiencies.

  • Vitamin KDepletion

    Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin K, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin K may be advisable to prevent or address potential deficiencies.

  • Vitamin EDepletion

    Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin E, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin E may be advisable to prevent or address potential deficiencies.

  • Vitamin ADepletion

    Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin A, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin A may be advisable to prevent or address potential deficiencies.

Other Health Impacts of Colesevelam

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