Colesevelam

Colesevelam is a medication used to lower cholesterol levels in adults with high cholesterol, as well as improve glycemic control in adults with type 2 diabetes. It works by binding to bile acids in the intestines, preventing their reabsorption and promoting their excretion from the body. This helps to decrease cholesterol levels in the bloodstream and improve blood sugar control. Colesevelam is typically taken in the form of tablets or a powder that can be mixed with liquid.

Overview Why It Happens Clinical Evidence Replacement Supplement Other Nutrients

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Colesevelam

Colesevelam & Vitamin D3

Depletes Vitamin D3. This medication is commonly used for High Cholesterol

Why Colesevelam affects Vitamin D3

Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin D3, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin D3 may be advisable to prevent or address potential deficiencies.

Clinical Evidence

Shojania AM, Grewar D. Hypoprothrombinemic hemorrhage due to cholestyramine therapy. CMAJ. 1986;134(6):609-610. M S Matsui et al. Drug-nutrient interaction. Clin Ther. 1982;4(6):423-40. Wakeman M. A Literature Review of the Potential Impact of Medication on Vitamin D Status. Risk Manag Healthc Policy. 2021 Aug 14;14:3357-3381. Robien K, Oppeneer SJ, Kelly JA, Hamilton-Reeves JM. Drug-vitamin D interactions: a systematic review of the literature. Nutr Clin Pract. 2013;28(2):194-208. doi:10.1177/0884533612467824.

Recommended Replacement

Chloecalciferol — 1,000 IU

Supplement Recommendation

Vitamin D3 (Cholcalciferol) (1000 IU) by Nordic Naturals — 25mcg

Other Nutrients Affected by Colesevelam

Folic Acid — Depletion
Vitamin K — Depletion
Vitamin E — Depletion
Vitamin A — Depletion

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