Vitamin D deficiency has been consistently associated with higher risk of metabolic problems, including insulin resistance and type 2 diabetes. A meta-analysis of 21 prospective studies following 76,220 participants and documenting 4,996 new type 2 diabetes cases found a clear, statistically significant inverse relationship between circulating 25(OH)D levels and future diabetes risk across diverse populations. In clinical research, people with type 2 diabetes typically show significantly lower vitamin D levels and higher HOMA-IR scores than healthy controls, with an inverse correlation between vitamin D status and insulin resistance that supports a potential mechanistic role of deficiency in the pathophysiology of insulin resistance. This medication is commonly used for High Cholesterol.
Xu, Z., Gong, R., Luo, G. et al. Association between vitamin D3 levels and insulin resistance: a large sample cross-sectional study. Sci Rep 12, 119 (2022). Jain PK, Nigotia P, Mishra A, Singh LP. Association of vitamin D deficiency with insulin resistance among type 2 diabetes mellitus patients - A case-control study. Bioinformation. 2025 Aug 31;21(8):2897-2900. Ehrampoush E, Mirzay Razzaz J, Arjmand H, Ghaemi A, Raeisi Shahraki H, Ebrahim Babaei A, Osati S, Homayounfar R. The association of vitamin D levels and insulin resistance. Clin Nutr ESPEN. 2021 Apr;42:325-332. Song Y, Wang L, Pittas AG, Del Gobbo LC, Zhang C, Manson JE, Hu FB. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care. 2013 May;36(5):1422-8.
Some side effects may be linked to nutrient depletion caused by this medication.
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin D3, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin D3 may be advisable to prevent or address potential deficiencies.
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin A, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin A may be advisable to prevent or address potential deficiencies.
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin E, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin E may be advisable to prevent or address potential deficiencies.
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to folic acid, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with folic acid may be advisable to prevent or address potential deficiencies.
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin K, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin K may be advisable to prevent or address potential deficiencies.