Cholestyramine

Cholestyramine is a medication used to lower high levels of cholesterol in the blood. It works by binding to bile acids in the intestines, preventing them from being reabsorbed into the blood. This results in the liver producing more bile acids, which in turn helps to lower cholesterol levels. Cholestyramine is often prescribed to patients with high cholesterol levels who are at risk of developing heart disease. It is typically taken orally as a powder or suspension.

Overview Why It Happens Clinical Evidence Replacement Other Nutrients

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Cholestyramine

Cholestyramine & Vitamin K

Depletes Vitamin K. This medication is commonly used for High Cholesterol

Why Cholestyramine affects Vitamin K

Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin K, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin K may be advisable to prevent or address potential deficiencies.

Clinical Evidence

A M Shojania et al. Hypoprothrombinemic hemorrhage due to cholestyramine therapy. CMAJ. 1986 Mar 15;134(6):609-10. M S Matsui et al. Drug-nutrient interaction. Clin Ther. 1982;4(6):423-40.K Vroonhof et al. Vitamin K deficiency and bleeding after long-term use of cholestyramine. Neth J Med. 2003 Jan;61(1):19-21.

Recommended Replacement

Vitamin K1 — 500 mcg

Other Nutrients Affected by Cholestyramine

Vitamin D3 — Depletion
Vitamin A — Depletion
Vitamin E — Depletion
Folic Acid — Depletion

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