Low zinc disrupts keratinocyte proliferation, collagen synthesis and epithelial repair, resulting in delayed wound healing, dermatitis and poor tissue regeneration. This medication is commonly used for Pain Management.
Experimental and clinical studies demonstrate that zinc deficiency is associated with skin lesions, delayed wound closure and abnormal inflammatory responses, while zinc repletion can improve healing outcomes in selected populations.
Lin PH, Sermersheim M et al. Zinc in wound healing modulation. Nutrients. 2017;9(1):16.; News-Medical. The role of zinc in immune health and wound healing. 2024.; Lopez EA et al. Systematic review and meta-analysis of the effect of zinc on wound healing. Nutr Clin Pract. 2025;40(2):123-135.
Some side effects may be linked to nutrient depletion caused by this medication.
Regular aspirin use, even at therapeutic doses, can lead to lower-than-normal levels of folate in the blood (serum folate). Additionally, aspirin might slightly increase the amount of folate excreted in urine, potentially disrupting the body's folate balance. For those taking regular aspirin therapy, folic acid supplementation should be considered to prevent a deficiency.
Studies indicate that medications like aspirin can increase zinc loss through urine. Zinc plays a vital role in wound healing, protein synthesis, cell reproduction, immunity, and vision. If you take aspirin regularly, consider monitoring zinc levels and supplementation may be beneficial to prevent a deficiency.
Regular use of aspirin (acetylsalicylic acid) can increase how much vitamin C your body gets rid of through urine, potentially leading to deficiency. If you take aspirin regularly, consider supplementing with vitamin C supplementation.
Research found that individuals hospitalized with heart disease and a history of aspirin use were nearly twice as likely to have low or borderline vitamin B12 levels compared to non-aspirin users. While this doesn't definitively prove aspirin causes B12 deficiency, it raises a potential link. Aspirin can irritate the stomach lining in some individuals. This is concerning because the stomach plays a crucial role in vitamin B12 absorption by producing hydrochloric acid and intrinsic factor. Both are essential for proper B12 uptake.