Zinc deficiency during childhood and adolescence is strongly linked to impaired linear growth and delayed sexual maturation, and is a recognized contributor to stunting in many low‑ and middle‑income countries. In some population studies, zinc deficiency has been present in over 30–40% of children, and zinc supplementation programs have been associated with modest but meaningful improvements in height gain over time. Clinically, even marginal zinc deficiency can quietly slow growth velocity and pubertal progression, making adequate zinc intake an important, often overlooked pillar of healthy growth and development. This medication is commonly used for Pain Management.
Abdollahi M, Ajami M, Abdollahi Z, Kalantari N, Houshiarrad A, Fozouni F, Fallahrokni A, Mazandarani FS. Zinc supplementation is an effective and feasible strategy to prevent growth retardation in 6 to 24 month children: A pragmatic double blind, randomized trial. Heliyon. 2019 Nov 1;5(11):e02581. Walravens PA, Krebs NF, Hambidge KM. Linear growth of low income preschool children receiving a zinc supplement. Am J Clin Nutr. 1983 Aug;38(2):195-201. Rerksuppaphol S, Rerksuppaphol L. Zinc supplementation enhances linear growth in school-aged children: A randomized controlled trial. Pediatr Rep. 2018 Jan 4;9(4):7294. Zinc deficiency as risk factor for stunting among children aged 2-5 years. (2017). Universa Medicina, 36(1), 11-18.
Some side effects may be linked to nutrient depletion caused by this medication.
Regular aspirin use, even at therapeutic doses, can lead to lower-than-normal levels of folate in the blood (serum folate). Additionally, aspirin might slightly increase the amount of folate excreted in urine, potentially disrupting the body's folate balance. For those taking regular aspirin therapy, folic acid supplementation should be considered to prevent a deficiency.
Studies indicate that medications like aspirin can increase zinc loss through urine. Zinc plays a vital role in wound healing, protein synthesis, cell reproduction, immunity, and vision. If you take aspirin regularly, consider monitoring zinc levels and supplementation may be beneficial to prevent a deficiency.
Regular use of aspirin (acetylsalicylic acid) can increase how much vitamin C your body gets rid of through urine, potentially leading to deficiency. If you take aspirin regularly, consider supplementing with vitamin C supplementation.
Research found that individuals hospitalized with heart disease and a history of aspirin use were nearly twice as likely to have low or borderline vitamin B12 levels compared to non-aspirin users. While this doesn't definitively prove aspirin causes B12 deficiency, it raises a potential link. Aspirin can irritate the stomach lining in some individuals. This is concerning because the stomach plays a crucial role in vitamin B12 absorption by producing hydrochloric acid and intrinsic factor. Both are essential for proper B12 uptake.