Folate deficiency impairs DNA synthesis, resulting in ineffective erythropoiesis, macrocytosis and megaloblastic anemia, often accompanied by glossitis, mucosal changes and fatigue. This medication is commonly used for Hypertension.
Hematology and nutrition reviews describe folate deficiency as a classic cause of megaloblastic anemia and mucosal abnormalities, frequently exacerbated by medications that antagonize folate metabolism.
O’Leary F, Samman S. Vitamin B12 in health and disease. Nutrients. 2010;2(3):299-316. (discussion of folate and B12 in megaloblastic anemia); Lešić S et al. The impact of vitamin deficiencies on oral manifestations. Dent J (Basel). 2024;12(4):109.
Some side effects may be linked to nutrient depletion caused by this medication.
Calcium channel blockers (CCBs), particularly nifedipine, can cause gum tissue overgrowth (gingival hyperplasia) in both men and women. Studies suggest a dose-dependent link with CCBs potentially doubling the risk. Studies also confirm a link between CCB use (like amlodipine and nifedipine) and gingival hyperplasia, even beyond factors like poor hygiene. Research suggests impaired folate uptake in gum tissue might be another key contributor. Supplementation with folate to help protect against CCB-induced hyperplasia may be beneficial.