Nutrient depletion caused by Amlodipine can lead to a range of health impacts. This medication is commonly used for Hypertension.
Amlodipine may deplete important nutrients your body relies on every day. These changes often occur gradually as medications affect nutrient absorption, metabolism, or utilization. Over time, low nutrient levels can contribute to fatigue, neurological symptoms, metabolic issues, and reduced resilience. Addressing these depletions can help support long-term health while continuing necessary treatment.
Folate depletion impairs one-carbon metabolism, leading to elevated homocysteine, endothelial dysfunction and potential promotion of atherothrombotic events.
Meta-analyses of randomized trials show that folic acid supplementation lowers homocysteine and modestly reduces stroke and overall cardiovascular disease risk in some populations, especially where baseline folate status is low, highlighting the adverse vascular profile of folate deficiency.
Li Y et al. Folic acid supplementation and the risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. J Am Heart Assoc. 2016;5(8):e003768.; Wang Y et al. The effect of folic acid in patients with cardiovascular disease: a meta-analysis. Medicine (Baltimore). 2019;98(38):e17106.; Miller ER et al. Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease. Am J Cardiol. 2010;106(4):517-527.
Read more about High Homocysteine & Vascular Risk