Trulicity & Vitamin D3
Depletes Vitamin D3. This medication is commonly used for Weight Loss
Why Trulicity affects Vitamin D3
GLP‑1 receptor agonists, used for diabetes and weight management, can raise the risk of vitamin D deficiency because they substantially reduce overall food intake in people who are often starting from a low baseline. Emerging data in GLP‑1 users show high rates of low vitamin D and other nutritional deficiencies, which may compound age and obesity related risks for bone loss and loss of muscle mass. To help support bone health, muscle maintenance, and immune function during rapid weight loss, many experts recommend ensuring adequate vitamin D through diet, sensible sun exposure, and vitamin D supplementation.
Clinical Evidence
Johnson B, Milstead M, Thomas O, McGlasson T, Green L, Kreider R, Jones R. Investigating nutrient intake during use of glucagon-like peptide-1 receptor agonist: a cross-sectional study. Front Nutr. 2025 Apr 25;12:1566498. Scott Butsch W, Sulo S, Chang AT, Kim JA, Kerr KW, Williams DR, Hegazi R, Panchalingam T, Goates S, Heymsfield SB. Nutritional deficiencies and muscle loss in adults with type 2 diabetes using GLP-1 receptor agonists: A retrospective observational study. Obes Pillars. 2025 Jun 10;15:100186. Urbina J, Salinas-Ruiz LE, Valenciano C, Clapp B. Micronutrient and Nutritional Deficiencies Associated With GLP-1 Receptor Agonist Therapy: A Narrative Review. Clin Obes. 2026 Feb;16(1):e70070. Kauser H, et al. Factors Showing the Growing Relation Between Vitamin D, Metabolic Syndrome, and Obesity in the Adult Population: A Systematic Review. Cureus. 2022 Jul 27;14(7):e27335. Takahashi F, et al. Vitamin Intake and Loss of Muscle Mass in Older People with Type 2 Diabetes: A Prospective Study of the KAMOGAWA-DM Cohort. Nutrients. 2021 Jul 8;13(7):2335. Sibal R, Balamurugan G, Langley J, Graham Y, Mahawar K. Macronutrient, Micronutrient Supplementation and Monitoring for Patients on GLP-1 Agonists: Can We Learn from Metabolic and Bariatric Surgery? Nutrients. 2025 Nov 23;17(23):3659.
Recommended Replacement
Vitamin D3 (as Cholecalciferol) — 75 mcg
Supplement Recommendation
Vitamin D3 (Cholcalciferol) (1000 IU) by Nordic Naturals — 25mcg
Other Nutrients Affected by Trulicity
- Folic Acid — Depletion
- Zinc — Depletion
- Iron — Depletion
- Calcium — Depletion
- Vitamin B12 — Depletion
- Magnesium — Suppression
- Vitamin B2 — Suppression
- Vitamin B6 — Suppression
- CoQ10 — Suppression
- Chromium — Suppression
- Potassium — Suppression
Get Support
Prolonged use of Trulicity can leave gaps in your nutrition. A targeted supplement can help restore balance while you continue treatment.
GLP-1 Support™
A bespoke formula designed to replenish the nutrients depleted by Trulicity.
Once Daily Capsule · Rx Not Required
Learn More