Depletes Vitamin B1. This medication is commonly used for Contraception
Studies suggest a potential for mild thiamine (vitamin B1) deficiency with long-term use of Oral Contraceptives (OCs). One finding showed that red blood cell activity of an enzyme dependent on thiamine (transketolase) decreased during OC treatment. This decrease indicates that the cells might not have enough thiamine to function optimally, suggesting a mild thiamine deficiency induced by the contraceptives. Supplementation with thiamine (vitamin B1) should be considered for women using OCs.
Briggs MH, Briggs M. Thiamine status and oral contraceptives. Contraception. 1975 Feb;11(2):151-4. doi: 10.1016/0010-7824(75)90025-6. PMID: 1112084.Anderson KE, Bodansky O, Kappas A. Effects of oral contraceptives on vitamin metabolism. Adv Clin Chem. 1976;18:247-87. Shikh EV, Makhova AA, Chemeris AV, Tormyshov IA. [Iatrogenic deficits of micronutrients]. Vopr Pitan. 2021;90(4):53-63. Russian. Bielenberg J. Folsäure- und Vitaminmangel durch orale Kontrazeptiva [Folic acid and vitamin deficiency caused by oral contraceptives]. Med Monatsschr Pharm. 1991 Aug;14(8):244-7. German. PMID: 1921842.
Vitamin B1 Thiamine — 10 mg
In older adults, low folate status has been associated with a higher risk of mild cognitive impairment (MCI) and faster cognitive decline over time, likely through effects on one‑carbon metabolism and homocysteine. Several longitudinal cohort studies have found that individuals with lower serum or red‑cell folate and higher homocysteine show steeper declines on memory and global cognition tests, and in some cohorts have a significantly higher incidence of MCI or dementia over follow‑up. The clinically important takeaway is that, when folate deficiency is detected and corrected (usually along with ensuring adequate vitamin B12), some patients demonstrate stabilization or modest improvement in cognitive performance, particularly when interventions are combined with aggressive management of vascular risk factors such as hypertension and diabetes.
Vitamin B12 Methylcobalamin by Pure Encapsulations — 0.2 mg