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Simvastatin + Sitagliptin
Depletes
Prolonged use of Simvastatin + Sitagliptin can impact 1 essential nutrient.
CoQ10
While studies demonstrate statins effectively lower LDL-C and apoB, research suggests they may also reduce CoQ10 levels. This vital antioxidant plays a crucial role in mitochondrial function, and deficiency can impact brain, muscle, kidney, and heart health. CoQ10 supplementation could be a helpful way to mitigate a potential deficiency when taking a statin therapy.
Replace with Ubiquinol/Ubiquinone (50mg of each)
Research: Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA...
Health Impact
Simvastatin + Sitagliptin-induced nutrient depletion can lead to a range of health problems
Statin-Related Muscle Pain & Fatigue
Randomized trials and meta-analyses in statin-treated patients have shown that CoQ10 depletion and/or low circulating levels are associated with muscle symptoms, while supplementation has produced mixed but suggestive improvements in statin-associated myalgia and muscle pain severity.
Research: Caso G et al. Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins. Am J Cardiol....
Low Mitochondrial Energy & Antioxidant Defense
Mechanistic and clinical studies link lower CoQ10 status with impaired oxidative phosphorylation and higher markers of oxidative stress, particularly in tissues with high metabolic demand such as myocardium and skeletal muscle.
Research: Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: cardiology and beyond. Antioxid Redox Signal....
Side Effects
Common side effects of Simvastatin + Sitagliptin, some of which may be related to nutrient depletion
Review
Some common side effects of Simvastatin + Sitagliptin may include:
- Headache
- Muscle pain or weakness
- Joint pain
- Diarrhea
- Constipation
- Nausea
- Upset stomach
- Flushing or redness of the skin
- Cold symptoms such as stuffy nose, sneezing, or sore throat
- Minor weight loss
Rare but serious side effects may include:
- Liver problems such as liver damage or liver failure
- Increased blood sugar levels
- Allergic reactions such as rash, hives, itching, swelling of the face, lips, tongue, or throat
- Severe muscle pain, tenderness, or weakness
- Unusual tiredness or weakness
- Dark urine or yellowing of the skin or eyes (jaundice)
It is important to consult with a healthcare provider if you experience any side effects while taking Simvastatin + Sitagliptin.
- Headache
- Muscle pain or weakness
- Joint pain
- Diarrhea
- Constipation
- Nausea
- Upset stomach
- Flushing or redness of the skin
- Cold symptoms such as stuffy nose, sneezing, or sore throat
- Minor weight loss
Rare but serious side effects may include:
- Liver problems such as liver damage or liver failure
- Increased blood sugar levels
- Allergic reactions such as rash, hives, itching, swelling of the face, lips, tongue, or throat
- Severe muscle pain, tenderness, or weakness
- Unusual tiredness or weakness
- Dark urine or yellowing of the skin or eyes (jaundice)
It is important to consult with a healthcare provider if you experience any side effects while taking Simvastatin + Sitagliptin.
Get Support
We've developed a formula to replenish the nutrients depleted by Simvastatin + Sitagliptin.
Shop Third-Party Supplements
COQ 10 (as Ubiquinone)
by Life Extension
The CoQ10 supplement by Life Extension is a high-quality dietary supplement designed to support cellular energy production and antioxidant protection, utilizing a bioavailable form of Coenzyme Q10.
Strength: 50 mg
Buy now
COQ 10 (as Ubiquinone)
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