Create an account to receive alerts on new research
SaveShareAsk AI
Simvastatin

Simvastatin & Magnesium

Suppresses absorption of Magnesium. This medication is commonly used for High Cholesterol

Why Simvastatin affects Magnesium

Magnesium supplements and statin medications both inhibit the HMG-CoA and have complementary effects to reducing the production of cholesterol. Magnesium has functions that are crucial to cardiovascular and general health as a catalyst to 300 healthy reactions in the body and 100 in the heart. The association between Magnesium supplementation and statins is also able to offer some protection for painful myopathy as a side effect induced by statins, which may also boost patient compliance. According to research, patients who received the statin drug atorvastatin along with a magnesium treatment had significantly increased levels of serum magnesium, HDL (the good cholesterol), as well as significantly decreased levels of total cholesterol, LDL cholesterol, and triglycerides.

Clinical Evidence

Roxana Nartea, et al. The Link between Magnesium Supplements and Statin Medication in Dyslipidemic Patients. Curr Issues Mol Biol. 2023 Apr; 45(4): 3146–3167. Published online 2023 Apr 5. doi: 10.3390/cimb45040205. El-Haggar Sahar M., Mostafa Tarek M. Role of Magnesium Supplement on Hyperlipidemia and L-CAT Level in Patient on Atorvastatin Therapy. Br. J. Pharm. Res. 2014;4:1521–1534. doi: 10.9734/BJPR/2014/11164

Recommended Replacement

Magnesium75mg

Related Health Impacts

Supplement Recommendation

Magnesium (as Magnesium Citrate) by Pure Encapsulations150 mg

Other Nutrients Affected by Simvastatin

Next Steps
Save this report and share it with your healthcare provider or a family member
Ask our expert AI assistant additional questions related to Simvastatin.