Saxenda & Vitamin B6
Suppresses absorption of Vitamin B6. This medication is commonly used for Weight Loss
Why Saxenda affects Vitamin B6
GLP-1 receptor agonists can substantially reduce overall food and micronutrient intake as appetite and meal size decline. In a prospective study of adults starting semaglutide or tirzepatide, vitamin B6 intake declined significantly over 24 weeks, supporting the importance of maintaining adequate B6 during therapy. However, other GLP-1 studies have not demonstrated a consistent B6 deficiency signal, so its role is best viewed as nutritional coverage during reduced intake rather than replacement of a nutrient directly depleted by GLP-1s. B6 is essential for amino acid metabolism, neurotransmitter synthesis, and cellular energy pathways.
Clinical Evidence
Babazadeh D, Therrien S, Fitch AK, Steinberg FM. Changes in food cravings, dietary quality, body composition, and dietary intake during GLP-1 receptor agonist therapy: The CRAVE study. Obes Pillars. 2026;19:100292.Richardson KM, Schembre SM, Jospe MR, Widmer A, Silver HJ. The influence of the glucagon-like peptide-1 receptor agonist, liraglutide, on dietary patterns and nutrient intakes in patients with obesity and prediabetes: A secondary analysis of a randomized controlled trial. Diabetes Obes Metab. 2025;27(7):3725-3735. Johnson B, Milstead M, Thomas O, McGlasson T, Green L, Kreider R, Jones R. Investigating nutrient intake during use of glucagon-like peptide-1 receptor agonist: a cross-sectional study. Front Nutr. 2025;12:1566498.
Recommended Replacement
Vitamin B6 (50% Pyridoxal-5′-Phosphate, 50% Pyridoxine Hydrochloride) — 10 mg of each
Supplement Recommendation
Vitamin B6 (50% Pyridoxine and 50% P-5-P) by Pure Encapsulations — 10 mg
Other Nutrients Affected by Saxenda
- Folic Acid — Depletion
- Vitamin B12 — Depletion
- Zinc — Depletion
- Vitamin D3 — Depletion
- Calcium — Depletion
- Iron — Depletion
- Magnesium — Suppression
- Potassium — Suppression
- Chromium — Suppression
- CoQ10 — Suppression
- Vitamin B2 — Suppression
Get Support
Prolonged use of Saxenda can leave gaps in your nutrition. A targeted supplement can help restore balance while you continue treatment.
GLP-1 Support™
A bespoke formula designed to replenish the nutrients depleted by Saxenda.
Once Daily Capsule · Rx Not Required
Learn More