Inadequate vitamin D undermines calcium absorption and bone remodeling, so chronic deficiency increases the risk of low bone mineral density, osteoporosis, and osteomalacia with bone pain and muscle weakness. Epidemiologic data have linked low 25‑hydroxyvitamin D levels with higher rates of fragility fractures, particularly hip and vertebral fractures in older adults, even after adjusting for age and baseline bone density. Clinically, correcting vitamin D deficiency, together with adequate calcium intake, resistance exercise, and fall‑prevention strategies, has been shown to improve bone mineral density and help reduce fracture risk in at‑risk populations. This medication is commonly used for High Cholesterol.
Bowden SA, Robinson RF, Carr R, Mahan JD. Prevalence of vitamin D deficiency and insufficiency in children with osteopenia or osteoporosis referred to a pediatric metabolic bone clinic. Pediatrics. 2008 Jun;121(6):e1585-90. Lv QB, Gao X, Liu X, Shao ZX, Xu QH, Tang L, Chi YL, Wu AM. The serum 25-hydroxyvitamin D levels and hip fracture risk: a meta-analysis of prospective cohort studies. Oncotarget. 2017 Jun 13;8(24):39849-39858. Brodrick, Siobhan E.M. Vitamin D insufficiency and deficiency: in search of a bone disease. Pathology Volume 58, Issue 2, March 2026, Pages 156-162. Weaver CM, Alexander DD, et al. Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int. 2016 Jan;27(1):367-76. Silva BC, Camargos BM, Fujii JB, Dias EP, Soares MM. Prevalência de deficiência e insuficiência de vitamina D e sua correlação com PTH, marcadores de remodelação óssea e densidade mineral óssea, em pacientes ambulatoriais [Prevalence of vitamin D deficiency and its correlation with PTH, biochemical bone turnover markers and bone mineral density, among patients from ambulatories]. Arq Bras Endocrinol Metabol. 2008 Apr;52(3):482-8. Portuguese
Some side effects may be linked to nutrient depletion caused by this medication.
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin D3, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin D3 may be advisable to prevent or address potential deficiencies.
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin E, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin E may be advisable to prevent or address potential deficiencies.
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to fat soluble vitamins like vitamin A, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with vitamin A may be advisable to prevent or address potential deficiencies.
Bile acid sequestrants work by binding to cholesterol and bile acids in the intestine, unfortunately, they can also bind to folic acid, hindering its uptake into the bloodstream. For individuals taking bile acid sequestrants, supplementing with folic acid may be advisable to prevent or address potential deficiencies.