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Propranolol

Propranolol & CoQ10

Depletes CoQ10. This medication is commonly used for Hypertension

Why Propranolol affects CoQ10

Coenzyme Q10 (CoQ10) plays a vital role in cellular energy production. However, our ability to produce CoQ10 naturally declines with age, and dietary sources rarely provide therapeutic levels. Additionally, beta-blocker medications can further deplete CoQ10 stores. Therefore, individuals taking beta-blockers may benefit from CoQ10 supplementation.

Clinical Evidence

Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, Fernández Vega A, de la Mata M, Delgado Pavón A, de Miguel M, Pérez Calero C, Villanueva Paz M, Cotán D, Sánchez-Alcázar JA. Coenzyme q10 therapy. Mol Syndromol. 2014 Jul;5(3-4):187-97. Hamada M, Kazatain Y, Ochi T, et al. Correlation between serum CoQ10 level and myocardial contractility in hypertensive patients. In Biomedical and Clinical Aspects of Coenzyme Q, vol 4, ed. K Folkers, Y Yamamura. Amsterdam: Elsevier, 1984, 263-70. Sarter B. Coenzyme Q10 and cardiovascular disease: a review. J Cardiovasc Nurs. 2002 Jul;16(4):9-20. Kishi T, Watanabe T, Folkers K. Bioenergetics in clinical medicine XV. Inhibition of coenzyme Q10-enzymes by clinically used adrenergice blockers of beta-receptors. Res Commun Chem Pathol Pharmacol. 1977 May;17(1):157-64.

Recommended Replacement

50% Ubiquinone and 50% Ubiquinol50 mg

Related Health Impacts

  • Statin-Related Muscle Pain & Fatigue

    Lower CoQ10 impairs mitochondrial ATP production in skeletal muscle, which can manifest as fatigue, myalgias and weakness, particularly in patients taking statins that further reduce endogenous CoQ10 levels.

  • Low Mitochondrial Energy & Antioxidant Defense

    CoQ10 is a key electron carrier in the mitochondrial respiratory chain and an important lipid-soluble antioxidant; depletion reduces cellular energy output and increases susceptibility of membranes and LDL particles to oxidative damage.

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