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Oxycodone + Aspirin

Oxycodone + Aspirin & Vitamin C

Depletes Vitamin C. This medication is commonly used for Pain Management

Why Oxycodone + Aspirin affects Vitamin C

Regular use of aspirin (acetylsalicylic acid) can increase how much vitamin C your body gets rid of through urine, potentially leading to deficiency. If you take aspirin regularly, consider supplementing with vitamin C supplementation.

Clinical Evidence

Schulz HU, Schürer M, Krupp S, Dammann HG, Timm J, Gessner U. Effects of acetylsalicylic acid on ascorbic acid concentrations in plasma, gastric mucosa, gastric juice and urine--a double-blind study in healthy subjects. Int J Clin Pharmacol Ther. 2004 Sep;42(9):481-7. Coffey G, Wilson CWM. Ascorbic acid deficiency and aspirin-induced haematemesis. BMJ 1975;I:208. Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet. 1971 May 8;1(7706):937-8.

Recommended Replacement

Vitamin C Ascorbic Acid200 mg

Related Health Impacts

  • Eye Bleeding & Vision Issues

    Vitamin C deficiency weakens collagen in capillary and vascular walls, so severe scurvy can present with ocular hemorrhages in the conjunctiva and retina that threaten vision if not treated. Case reports and small series describe retinal hemorrhages, flame‑shaped hemorrhages, and even retrobulbar bleeding compressing the optic nerve, which can lead to optic neuropathy and visual loss in advanced cases. The encouraging point is that, when vitamin C deficiency is recognized early and promptly repleted, many ocular hemorrhages and visual symptoms can partially or fully resolve, making it critical to consider vitamin C status in patients with otherwise unexplained ocular bleeding and visual complaints.

Supplement Recommendation

Vitamin C (Ascorbic Acid) by Pure Encapsulations200 mcg

Other Nutrients Affected by Oxycodone + Aspirin

Next Steps
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