Depletes CoQ10. This medication is commonly used for Diabetes
Biguanide (anti-diabetic) drugs have been found in scientific evidence to decrease serum levels of coenzyme Q10. Type 2 diabetes can increase oxidative stress in the body, weakening its defenses and potentially harming cells. CoQ10, a powerful antioxidant, plays a crucial role in protecting cells from this damage. CoQ10 supplementation may help restore these levels, potentially improving mitochondrial function and protecting the kidneys from damage.
Sourris KC, Harcourt BE, Tang PH, Morley AL, Huynh K, Penfold SA, Coughlan MT, Cooper ME, Nguyen TV, Ritchie RH, Forbes JM. Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes. Free Radic Biol Med. 2012 Feb 1;52(3):716-723.Miyake Y, Shouzu A, Nishikawa M, et al. Effect of treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on serum coenzyme Q10 in diabetic patients. Arzneimittelforschung. 1999;49(4):324-329. Kishi T, et al. Bioenergetics in clinical medicine. XI. Studies on CoQ and diabetes mellitus. J Med 1976;7: 307-321.
Ubiquinol/Ubiquinone — 50mg of each
Lower CoQ10 impairs mitochondrial ATP production in skeletal muscle, which can manifest as fatigue, myalgias and weakness, particularly in patients taking statins that further reduce endogenous CoQ10 levels.
CoQ10 is a key electron carrier in the mitochondrial respiratory chain and an important lipid-soluble antioxidant; depletion reduces cellular energy output and increases susceptibility of membranes and LDL particles to oxidative damage.