Depletes Zinc. This medication is commonly used for Hypertension
This drug is a comprehensive combination of a thiazide diuretic and angiotensin receptor blocker. Thiazide diuretics, a common medication for high blood pressure, can increase how much zinc your body gets rid of through urine. It's advisable to monitor your blood zinc levels while taking these medications and consider zinc supplementation. Studies have shown that treatment with medications like Angiotensin Receptor Blockers (ARBs) can lead to zincuria, which is increased urinary excretion of zinc. This increased excretion may potentially lead to zinc deficiency in some individuals and therefore supplementation should be considered.
Cohen N, Golik A. Zinc balance and medications commonly used in the management of heart failure. Heart Fail Rev. 2006 Mar;11(1):19-24. Effect of clopamide, a thiazide diuretic, on copper and zinc levels in hypertensive patients. J Am Coll Nutr. 1991 Feb;10(1):34-7. A J Reyes, et al. Diuretics and zinc. Afr Med J. 1982 Sep 4;62(11):373-5. M J du Preez et al. Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract. 2013 Aug;67(8):717-25. Maya Koren-Michowitz, Victor Dishy, Ronit Zaidenstein, Orit Yona, Sylvia Berman, Joshua Weissgarten, Ahuva Golik, The effect of losartan and losartan/hydrochlorothiazide fixed-combination on magnesium, zinc, and nitric oxide metabolism in hypertensive patients: A prospective open-label study, American Journal of Hypertension, Volume 18, Issue 3, March 2005, Pages 358–363. Cohen, N., Golik, A. Zinc balance and medications commonly used in the management of heart failure. Heart Fail Rev 11, 19–24 (2006).
Zinc (as zinc bisglycinate and (TRAACS™) — 12.5 mg
Zinc Bisglycinate by Pure Encapsulations — 15 mg