Lopid

Lopid is the brand name for the prescription medication Gemfibrozil, which is used to lower cholesterol and triglyceride levels in the blood. It belongs to a class of drugs known as fibrates. Gemfibrozil works by increasing the breakdown of fats and decreasing the production of triglycerides in the liver. It is typically used in combination with a healthy diet and exercise to reduce the risk of heart disease and stroke in patients with high cholesterol and triglyceride levels.

Overview Why It Happens Clinical Evidence Replacement

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Lopid

Lopid & B12

Suppresses absorption of B12. This medication is commonly used for High Cholesterol

Why Lopid affects B12

Research demonstrates that fibrates, particularly fenofibrate, are known to increase homocysteine levels. Elevated levels of homocysteine is associated with increased risk of a range of health problems including atherosclerosis, stroke, and neurological diseases, and vitamin Bs including vitamin B12 helps facilitate the breakdown of homocysteine and may be helpful in reducing homocysteine levels.

Clinical Evidence

Dierkes J, Westphal S, Kunstmann S, Banditt P, Lössner A, Luley C. Vitamin supplementation can markedly reduce the homocysteine elevation induced by fenofibrate. Atherosclerosis. 2001 Sep;158(1):161-4. doi: 10.1016/s0021-9150(00)00766-8. PMID: 11500187. Robinson C, Weigly E. Basic Nutrition and Diet Therapy. New York: Macmillan, 1984, 46–54.

Recommended Replacement

Vitamin B12 (Methylcobalamin) — 100 mcg

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