Depletes Magnesium. This medication is commonly used for Hypertension
This drug is a comprehensive combination of a thiazide diuretic and ACE inhibitor. Taking thiazide diuretics long-term can increase magnesium loss. Monitoring magnesium levels and considering supplementation might be necessary when taking thiazide diuretics for an extended period of time.
Cunha A.R., D’El-Rei J., Medeiros F., Umbelino B., Oigman W., Touyz R.M., Neves M.F. Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women. J. Hypertens. 2017;35:89–97. Martin B, Milligan K. Diuretic-associated hypomagnesiumia in the elderly. Arch Intern Med 1987;147:1768–71. Whang R, Whang DD, Ryan MP. Refractory potassium repletion. A consequence of magnesium deficiency. Arch Intern Med 1992;152:40-5.Gröber U., Schmidt J., Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015;7:8199–8226. doi: 10.3390/nu7095388
Magnesium Citrate — 50 mg
Magnesium depletion destabilizes neuromuscular transmission and ATP-dependent muscle relaxation, which can cause muscle cramps, tremors, weakness and restless legs.
Low magnesium interferes with cardiac myocyte electrophysiology and vascular tone, predisposing to premature beats, arrhythmias and elevated blood pressure.
Magnesium (as Magnesium Citrate) by Pure Encapsulations — 150 mg