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Hydroflumethizide

Hydroflumethizide & Zinc

Depletes Zinc. This medication is commonly used for Hypertension

Why Hydroflumethizide affects Zinc

Thiazide diuretics, a common medication for high blood pressure, can increase how much zinc your body gets rid of through urine. It's advisable to monitor your blood zinc levels while taking these medications and consider zinc supplementation.

Clinical Evidence

Cohen N, Golik A. Zinc balance and medications commonly used in the management of heart failure. Heart Fail Rev. 2006 Mar;11(1):19-24. Effect of clopamide, a thiazide diuretic, on copper and zinc levels in hypertensive patients. J Am Coll Nutr. 1991 Feb;10(1):34-7. doi: 10.1080/07315724.1991.10718123. A J Reyes, et al. Diuretics and zinc. Afr Med J. 1982 Sep 4;62(11):373-5. M J du Preez et al.

Recommended Replacement

Zinc (as zinc bisglycinate and (TRAACS™)12.5mg

Related Health Impacts

  • Age-Related Vision Loss

    Low zinc status has been linked to a higher risk and faster progression of age-related macular degeneration (AMD), in part because zinc is concentrated in the retina and supports antioxidant defenses there. In the landmark AREDS trial, a supplement formula containing zinc (80 mg as zinc oxide), along with antioxidants, reduced the risk of progression to advanced AMD by about 25% in people with intermediate disease or advanced disease in one eye over roughly 5 years. Other research has shown that inadequate zinc intake is more common in older adults with AMD, reinforcing the idea that maintaining healthy zinc levels may be an important, and often overlooked, strategy for preserving macular health with age.

  • Brain Fog & Neurological Effects

    Zinc deficiency has been associated with a range of neurological and behavioral changes, including increased irritability, poor attention, and slowed cognitive processing. In children, low zinc status has been linked to poorer performance on tests of attention, memory, and school achievement, and some trials have found that zinc supplementation can modestly improve certain cognitive scores, especially in previously deficient populations. Clinically, even mild zinc deficiency may present with subtle symptoms such as mood changes, reduced stress tolerance, and “brain fog,” which can easily be overlooked but may improve when zinc status is corrected.

  • Fertility & Hormone Problems

    Closely linked to reproductive and hormonal problems in both men and women, zinc deficiency can contribute to hypogonadism, low testosterone, reduced sperm count, and menstrual irregularities. In men, low zinc status has been associated with decreased serum testosterone, reduced sperm density and motility, and poorer overall semen quality, while zinc repletion in deficient individuals has been shown to improve some of these parameters. In women, inadequate zinc intake is tied to more frequent cycle disturbances, dysmenorrhea, and potential impacts on ovulation and fertility, underscoring zinc’s important role in healthy hormonal balance and reproductive function.

Supplement Recommendation

Zinc Bisglycinate by Pure Encapsulations15 mg

Other Nutrients Affected by Hydroflumethizide

Next Steps
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