Hydrochlorothiazide + Spironolactone is a combination medication that is used to treat high blood pressure and fluid retention (edema) caused by various conditions such as heart failure, liver disease, or kidney disease. Hydrochlorothiazide is a diuretic (water pill) that helps eliminate excess salt and water from the body. Spironolactone is a potassium-sparing diuretic that helps prevent the body from absorbing too much salt and keeps potassium levels from getting too low.<br /><br />This combination medication is typically prescribed when a single medication is not sufficient to control blood pressure or fluid retention. It should only be taken as prescribed by a healthcare provider, as it can cause side effects such as dizziness, headache, increased urination, and electrolyte imbalances.