Low or deficient vitamin C status can matter more than people realize because it can show up as everyday problems they already have, like bleeding gums when they brush or cuts and scrapes that seem slow to heal. Low vitamin C weakens collagen formation, making blood vessels in the gums and skin more fragile and increasing the risk of bleeding gums, easy bruising, and rough, dry skin. Clinical periodontal studies also show that ascorbic acid used alongside standard care can improve bleeding on probing, plaque and gingival indices, clinical attachment level, pocket depth, and gum aesthetics, supporting its role in healthier gums and more efficient healing of both oral tissues and skin. This medication is commonly used for High Cholesterol.
Murererehe J, Uwitonze AM, Nikuze P, Patel J and Razzaque MS (2022) Beneficial Effects of Vitamin C in Maintaining Optimal Oral Health. Front. Nutr. 8:805809. Ruzijevaite G, Acaite E, Jagelaviciene E. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review. Medicina (Kaunas). 2024 Dec 11;60(12):2041. Al-Niaimi F, Chiang NYZ. Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. J Clin Aesthet Dermatol. 2017 Jul;10(7):14-17. Epub 2017 Jul 1. Fitzpatrick, R.E. and Rostan, E.F. (2002), Double-Blind, Half-Face Study Comparing Topical Vitamin C and Vehicle for Rejuvenation of Photodamage. Dermatologic Surgery, 28: 231-236. Lassig AAD, Wilson AC, Jungbauer WN, Joseph AM, Lindgren B, Odland R. The Effects of Supplemental Vitamin C in Mandibular Fracture Patients: A Randomized Clinical Trial. Recent Progress in Nutrition 2023. Tajari F, Toloue Ghamari B, Jafari Kafiabadi M, Shariatzade H, Biglari F, Mahmoudi Nasab O, Salavati Mohammadi N, Najd Mazhar F. Effect of Vitamin C Injection on Flexor Tendon Healing in Zone II: A Randomized Controlled Trial. Cureus. 2026 Jan 22;18(1):e102075.
Some side effects may be linked to nutrient depletion caused by this medication.
Research demonstrates that fibrates, particularly fenofibrate, are known to increase homocysteine levels. Elevated levels of homocysteine is associated with increased risk of a range of health problems including atherosclerosis, stroke, and neurological diseases, and vitamin Bs including vitamin B12 helps facilitate the breakdown of homocysteine and may be helpful in reducing homocysteine levels.
Fenofibrate has been shown in studies to increase the toxic effect of ultraviolet (UV) radiation that may lead to side effects such as hives, itching, and skin rash. Taking vitamin C before UV exposure is found in research to significantly help block UV-fenofibrate effects on the skin. Vitamin C supplementation should be considered when taking this drug therapy.
Research demonstrates that fibrates, particularly fenofibrate, are known to increase homocysteine levels. Elevated levels of homocysteine is associated with increased risk of a range of health problems including atherosclerosis, stroke, and neurological diseases, and vitamin Bs including vitamin B6 helps facilitate the breakdown of homocysteine and may be helpful in reducing homocysteine levels.
Fenofibrate has been shown in studies to increase the toxic effect of ultraviolet (UV) radiation that may lead to side effects such as hives, itching, and skin rash. Taking vitamin E before UV exposure is found in research to significantly help block UV-fenofibrate effects on the skin. Vitamin E supplementation should be considered when taking this drug therapy.