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Ezetimibe + Simvastatin
Depletes
Prolonged use of Ezetimibe + Simvastatin can impact 1 essential nutrient.
CoQ10
Studies have shown that HMG CoA Reductase Inhibitors (also called statins) not only lower LDL-C and apoB plasma levels but also platelet levels of Coenzyme Q10 (CoQ10). This powerful antioxidant is mostly concentrated in the mitochondria with multiple metabolic functions and a deficiency can negatively affect many parts of the body including the brain, muscles, kidneys and heart. Supplementation with CoQ10 may be beneficial to help protect against a deficiency when on a statin therapy.
Replace with Ubiquinol/Ubiquinone (50mg of each)
Research: Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a...
Health Impact
Ezetimibe + Simvastatin-induced nutrient depletion can lead to a range of health problems
Statin-Related Muscle Pain & Fatigue
Randomized trials and meta-analyses in statin-treated patients have shown that CoQ10 depletion and/or low circulating levels are associated with muscle symptoms, while supplementation has produced mixed but suggestive improvements in statin-associated myalgia and muscle pain severity.
Research: Caso G et al. Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins. Am J Cardiol....
Low Mitochondrial Energy & Antioxidant Defense
Mechanistic and clinical studies link lower CoQ10 status with impaired oxidative phosphorylation and higher markers of oxidative stress, particularly in tissues with high metabolic demand such as myocardium and skeletal muscle.
Research: Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: cardiology and beyond. Antioxid Redox Signal....
Side Effects
Common side effects of Ezetimibe + Simvastatin, some of which may be related to nutrient depletion
Review
Some common side effects of Ezetimibe + Simvastatin may include:
1. Headache
2. Muscle pain
3. Joint pain
4. Stomach pain
5. Diarrhea
6. Fatigue
7. Nausea
8. Constipation
9. Dizziness
10. Rash
In rare cases, Ezetimibe + Simvastatin may cause more serious side effects such as liver problems, muscle damage, and allergic reactions. It is important to consult with your healthcare provider if you experience any persistent or severe side effects while taking this medication.
1. Headache
2. Muscle pain
3. Joint pain
4. Stomach pain
5. Diarrhea
6. Fatigue
7. Nausea
8. Constipation
9. Dizziness
10. Rash
In rare cases, Ezetimibe + Simvastatin may cause more serious side effects such as liver problems, muscle damage, and allergic reactions. It is important to consult with your healthcare provider if you experience any persistent or severe side effects while taking this medication.
Get Support
We've developed a formula to replenish the nutrients depleted by Ezetimibe + Simvastatin.
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COQ 10 (as Ubiquinone)
by Life Extension
The CoQ10 supplement by Life Extension is a high-quality dietary supplement designed to support cellular energy production and antioxidant protection, utilizing a bioavailable form of Coenzyme Q10.
Strength: 50 mg
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COQ 10 (as Ubiquinone)
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